2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

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The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (252):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-168230
    SMARCA2 ligand-9 1997320-33-8
    SMARCA2 ligand-9 is the ligand of SMARCA2. SMARCA2 ligand-9 can be used to synthesize PROTAC SMARCA2 degrader-27 (HY-168229).
    SMARCA2 ligand-9
  • HY-168676
    STING ligand-2 1307526-16-4
    STING ligand-2 is the ligand for STING, that can be used as target protein ligand in synthesis of PROTAC degrader STING-IN-10 (HY-168554).
    STING ligand-2
  • HY-168683
    CDK8 ligand 1 2924557-38-8
    CDK8 ligand 1 is the ligand of CDK8. CDK8 ligand 1 can be used to synthesize LL-K8-22 (HY-149209).
    CDK8 ligand 1
  • HY-135832
    Demethyl-RSL3 2375354-13-3
    Demethyl-RSL3 is a ligand for target protein for pROTAC.
    Demethyl-RSL3
  • HY-162841
    HPK1 ligand 1
    HPK1 ligand 1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). HPK1 ligand 1 can be used for synthesis PROTAC PD-L1 degrader-2 (HY-162816).
    HPK1 ligand 1
  • HY-168195
    DYR530 2410298-39-2
    DYR530 is a ligand for target protein (protein kinases DYRK1A) for PROTAC (HY-168194).
    DYR530
  • HY-169439
    Temozolomide-amino hydrochloride 449187-98-8
    Temozolomide-amino hydrochloride (compound 8) is an activity control for the target protein ligand of Naph-Se-TMZ (HY-169433).
    Temozolomide-amino hydrochloride
  • HY-169374
    Naproxen Gilteritinib 1373410-40-2
    Naproxen Gilteritinib is the active reference substance of Gilteritinib (HY-12432). Gilteritinib is the target protein ligand of PROTAC degrader LWY713 (HY-157213).
    Naproxen Gilteritinib
  • HY-164326
    KAL-21404358 1065573-84-3
    KAL-21404358 is a ligand for target protein for pROTAC.
    KAL-21404358
  • HY-168237
    SMARCA2 ligand-10 3024271-84-6
    SMARCA2 ligand-10 is a ligand for a target protein, used for the synthesis of PROTAC SMARCA2 degrader-28(HY-168236).
    SMARCA2 ligand-10
  • HY-167701
    OBHSA 1404508-27-5
    OBHSA is a selective estrogen receptor (ERα) degrader. OBHSA blocks the cell cycle by degrading cyclin D1, thereby overcoming Tamoxifen (HY-13757A) resistance. OBHSA also triggers excessive activation of the unfolded protein response (UPR) by inducing an increase in intracellular reactive oxygen species, ultimately leading to cell apoptosis. In addition, OBHSA can also be used as an ERα ligand to synthesize PROTAC degraders.
    OBHSA
  • HY-W599025
    5-Br-4-Cl-Pyrrolo-pyroxypyridine 2914920-46-8
    5-Br-4-Cl-Pyrrolo-pyroxypyridine is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). 5-Br-4-Cl-Pyrrolo-pyroxypyridine can be used for synthesis PROTAC GSPT1 degrader-1 (HY-159609).
    5-Br-4-Cl-Pyrrolo-pyroxypyridine
  • HY-168685
    c-Myc ligand 1 1942834-87-8
    c-Myc ligand 1, a c-Myc inhibitor, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). c-Myc ligand 1 can be used for synthesis PROTAC c-Myc inhibitor 7 (HY-148837).
    c-Myc ligand 1
  • HY-111852
    GNF5-amido-Me 778277-37-5
    GNF5-amido-Me, the GNF5 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER.
    GNF5-amido-Me
  • HY-168611
    PROTAC IRAK4 ligand-4 2434841-55-9
    PROTAC IRAK4 ligand-4 is a Ligand for Target Protein for PROTAC with antitumor activity. PROTAC IRAK4 ligand-4 can be used to synthesize PROTAC IRAK4 degrader-12 (HY-168586).
    PROTAC IRAK4 ligand-4
  • HY-161794
    SP3N
    SP3N is a specific degrader of the prolyl isomerase FKBP12. The alkylamine of SP3N is metabolized to a reactive aldehyde (SP3CHO), which recruits the SCFFBXO22 ligase for FKBP12 degradation. SP3N may be used in research for cancer.
    SP3N
  • HY-168700
    G12D ligand 1
    G12D ligand 1 is a Ligand for Target Protein for PROTAC. G12D ligand 1 can be used to synthesize Setidegrasib (HY-148273).
    G12D ligand 1
  • HY-169980
    Mivebresib-alkyne 2409674-37-7
    Mivebresib-alkyne (Compound 25), a Mivebresib (HY-100015) derivative, can be used for BRD4 targeted PROTAC synthesis through click reaction.
    Mivebresib-alkyne
  • HY-170334
    ER ligand-7
    ER ligand-7 is the ligand for estrogen receptor, and can be used for synthesis of PROTAC ER Degrader-15 (HY-170332) as ligand for target protein.
    ER ligand-7
  • HY-168542
    TTK ligand 2
    TTK ligand 2 is a monopolar spindle 1 (TTK) ligand that can be used in the synthesis of PROTACT (HY-168540).
    TTK ligand 2